Solutions


Our Solutions

digzyme's solutions continue to expand from analysis based on our core technology to manufacturing.


Enzyme Development Consulting

We provide consulting for new business development initiatives starting with enzymes. For instance, if you want to start a new business using bioprocesses, or advance the biologization of petrochemical-derived products, we offer solutions. Our consulting integrates bioinformatics-based analysis to address these challenges.

Finding, Improving, and Collecting Enzymes

We design the enzymes you desire through enzyme discovery (Moonlight™) and improvement (Spotlight™) using bioinformatics. Additionally, we accumulate the designed enzymes in a library (Designed Library™), allowing us to promptly provide enzymes tailored to industrial applications.

Manufacturing Enzymes or Compounds

This is a research and development service aimed at the manufacturing and sales of enzymes and compounds. Utilizing our enzyme library, we develop a series of processes to efficiently produce enzymes and compounds in large quantities.

  1. We construct microorganisms for the production of enzymes and compounds through genetic engineering.
  2. We evolve these microorganisms to optimize them for producing larger quantities of enzymes and compounds.
  3. The enzymes and compounds produced in small-scale cultures in the laboratory are scaled up for mass production.

Solutions Menu

Enzyme Development Consulting

Bio-synthesis Pathway Exploration

In bio-synthesis pathway exploration, we search for pathways to bio-produce the target compound. For unknown enzyme reactions included in the pathway, we calculate their similarity to known enzyme reactions in the database and select the most feasible bio-synthesis pathways.

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Finding, Improving, and Collecting Enzymes

Moonlight™

Moonlight™ is an integrated development platform for bio-process design that searches for the biosynthesis pathways and necessary enzyme reactions for the target compound. It conducts in silico activity evaluation of the discovered enzymes.

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Spotlight™

Spotlight™ is a platform that predicts various properties (activity, heat resistance, solubility, stability) of enzyme variants using a machine learning model, based on the amino acid sequence of the target enzyme.

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Similar Reaction Exploration

In Similar Reaction Exploration, we search for enzymes capable of catalyzing unknown chemical reactions. We acquire a list of similar enzyme reactions from the database based on substrate and product information and search for corresponding enzyme genes.

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Similar Enzyme Exploration

In Similar Enzyme Exploration, we search for enzymes systematically and functionally similar to your desired enzyme from billions of proteins in open databases. It's possible to conduct both focused searches on specific species and broad, unrestricted searches.

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Metagenomic Analysis

In Metagenomic Analysis, we extract protein sequences similar to the target protein sequence from the vast sequence space of metagenomic data. We search for similar sequences based on homology and domain commonality.

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Structural Modeling

In Structural Modeling, we predict the 3D structure of proteins whose 3D structures are not determined. We estimate the 3D structure using the optimal prediction method based on the primary sequence information of the target protein and generate it as PDB data.

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Enzyme Activity Pocket Prediction

In Enzyme Activity Pocket Prediction, we predict the location of the substrate-binding pocket from the 3D structure of your specified enzyme. The 3D structure of the enzyme required for input can use either public data or a structure predicted from the primary sequence.

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Enzyme-Substrate Docking

In Enzyme-Substrate Docking, we analyze how the specified enzyme and substrate form a complex. By statistically analyzing the positional relationship between the enzyme and substrate, we can determine whether the substrate will react with the target enzyme.

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Molecular Dynamics

In Molecular Dynamics, we simulate the motion of your specified enzyme-substrate complex using molecular dynamics methods. It tracks the possible configurations of the substrate within the pocket and the structural changes of the protein due to substrate binding.

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Polymer Dynamics

In Polymer Dynamics, we predict the affinity between your specified enzyme and polymer compounds. Using trajectories generated by molecular dynamics methods, we calculate interaction energy metrics and evaluate reactivity.

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Manufacturing Enzymes or Compounds

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